Non-Genetic Hearing Loss – Theory Question
May 30, 2021
Estimated reading time: 3 min
In this question
- 1. INFECTIONS​1​
- 2. Congenital CMV Infection​2​
- 3. Congenital Toxoplasmosis
- 4. Congenital Syphilis
- 5. Rubella​5​
- 6. Attention -
- 7. Measles and Mumps
- 8. Herpes Simplex Encephalitis
- 9. Bacterial Meningitis
- 10. TOXIC DRUGS AND CHEMICALS - Hearing loss
- 11. Aminoglycosides
- 12. Loop diuretics
- 13. Retinoids
- 14. Antimalarials
- 15. Cisplatin
- 16. HYPOXIA AND ANOXIA
- 17. HYPERBILIRUBINEMIA
- 18. RECURRENT OTITIS MEDIA AND MASTOID DISEASE
- 19. NEONATAL INTENSIVE CARE
- 20. EAR OR TEMPORAL BONE TRAUMA
- 21. PERILYMPHATIC FISTULA
- 22. NOISE-INDUCED HEARING LOSS
INFECTIONS​1​
Congenital CMV Infection​2​
- CMV affects ~1% of live newborns
- Only 10% exhibit signs of CMV inclusion disease:
- Mental retardation
- Severe to profound hearing loss
- Ocular problems (eg. chorioretinitis with optic atrophy)
- Other: language or learning disabilities, cerebral palsy, jaundice, microcephaly, growth retardation
- 15% who are asymptomatic at birth most commonly develop progressive bilateral SNHL
- Onset after 1st year of life
- Essentially all infants with symptomatic congenital CMV are products of pregnancies involving primary maternal infection
- Investigations to determine prenatally infected newborns are difficult because perinatally infected infants commence excreting virus as early as 3 to 12 weeks
Congenital Toxoplasmosis
- Cats are primary reservoirs
- Hearing Loss occurs in ~25% of untreated cases
- Diagnosis by detecting specific antibodies in serum, plasma, SSF and intraocular fluid
- Intensive therapeutic intervention with primarily infected expectant mothers and postnatal treatment of congenitally infected infants minimizes fetal damage and may prevent the emergence of sensory deficits.
To read full content, please consider buying the membership
Available Plans
Views: 356