OSTEORADIONECROSIS
- 1. What is Osteoradionecrosis (ORN)
- 2. Osteoradionecrosis of Temporal bone
- 3. Grades of disease:
- 4. Classifications of Osteoradionecrosis-
- 5. Frequency:
- 6. Etiology:
- 7. What are the Risk Factors
- 8. Pathophysiology of Osteoradionecrosis:
- 9. Work-up for Osteoradionecrosis:
- 10. Treatment:
- 11. Hyperbaric Oxygen Therapy:
What is Osteoradionecrosis (ORN)
Condition of nonvital bone in a site of radiation injury.
Can be spontaneous, but it most commonly results from tissue injury.
Apparently innocuous forms of trauma as denture-related injury, ulcers, or tooth extraction can overwhelm the reparative capacity of radiation-injured bone.
Osteoradionecrosis of Temporal bone
Radiation to the skull base can also result in bony necrosis of the temporal bone, termed
osteoradionecrosis (ORN)
The external ear canal (EAC) can be affected with ulceration, epithelial thickening with stenosis, fibrosis, atrophy of cerumen glands and cholesteatoma. Radiation to the middle ear has been shown to cause mucosal hypertrophy, loss of ciliary function, ossicular necrosis and Eustachian tube obstruction; which in turn causes serous otitis media, tympanic membrane atelectasis, cholesteatoma and chronic inflammation. Radiation damage to the inner ear was shown to cause sensorineural hearing loss and vestibular impairment, with histologic evidence of damage to the stria vascularis,
spiral ligament, basilar membrane and destruction of cells within the Organ of Corti Very
rarely the facial nerve can be damaged, producing paralysis or paresis.
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