Photodynamic therapy – DNB ENT THEORY
Photodynamic therapy​1​
Form of phototherapy using nontoxic light-sensitive compounds that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells.
Recognised as a treatment strategy which is both minimally invasive and minimally toxic.
Components
Most modern PDT applications involve three key components:
1 Photosensitizer
2 Light source
3 Tissue oxygen
The combination of these three components leads to the chemical destruction of any tissues which have either selectively taken up the photosensitizer or have been locally exposed to light.
The appropriatewavelength of light source excites the photosensitizer to produce reactive oxygen species. These reactive oxygen species generated through PDT are free radicals (Type I PDT) generated through electron abstraction- or transfer- from a substrate molecule and highly reactive state of oxygen known as singlet oxygen (Type II PDT).
Procedure
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