Wound Healing
- 1. Phases of Healing
- 2. Mechanisms involved
- 3. Types of wound closure -
- 4. Classification of Wounds Closure
- 5. Classification of wounds -
- 6. Intrinsic and extrinsic factors
- 7. Extracellular Matrix Metabolism
- 8. Wound Contraction
- 9. Epithelialiation-
- 10. Extrinsic Factors
- 11. Genetic Disorders of connective tissue metabolism
- 12. Best practices to improve wound healing
- 13. Causes of nonhealing of wound-
- 14. Common nonhealing wounds include -
Phases of wound healing:
- Coagulation phase,
- Inflammatory phase
- Fibroplasias proliferative phase and Remodeling phase
Phases of Healing
Coagulation
-damaged vessels and lymphatic trigger a cascade of events:
-vasoconstriction; mast cell release of vasoactive compounds: bradykinin, serotonin, histamine; diapedesis of cells into wound; hemostatic clot of platelets
-platelets release clotting factors to produce fibrin; also produce several essential cytokines which modulate the subsequent wound healing events
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Inflammation
-migration of leukocytes into the wound
-24h:Â predominantly PMNs, then by macrophages.
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Fibroplasia
-fibrous protein collagen is synthesized
-cross-linking of collagen provides strength and integrity
-increased synthesis within 10h of injury
-synthesis peaks after 5-7 days and then declines gradually
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Remodelling
-acute and chronic inflammatory cells diminish gradually, angiogenesis ceases, and fibroplasias ends
-equilibrium between collagen synthesis and collagen degradation is gradually restored.Â
Scott mentions – “Inflammation, Proliferation and Remodelling”
Mechanisms involved
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